May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By
Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer. Vykoukal J, et al.Nat Commun, 2020 Aug 27. PMID 32855410, Free PMC Article Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the Caveolin - What does Caveolin stand for? The Free DictionaryLooking for online definition of Caveolin or what Caveolin stands for? Caveolin is listed in the World's largest and most authoritative dictionary database of abbreviations and
ELISA Kits detecting Caveolin 1 can be used to research Host-virus interaction or to study Congenital generalized lipodystrophy 3 (CGL3). Caveolin 1, also known as PPH3, is a full name of caveolin 1, caveolae protein, 22kDa. Caveolin Medical Definition Merriam-Webster Medical Mar 06, 2003 · Medical definition of caveolin:any of several membrane proteins that are the major structural components of caveolae.
Park et al., "Caveolin 1 eion correlates with poor prognosis and focal adhesion kinase eion in gastric cancer," Pathobiology, vol. Prognostic Value of Metastatic Tumoral Caveolin-1 Eion in Patients with Resected Gastric Cancer Caveolin-1 Antibody (7C8) (NB100-615):Novus BiologicalsCaveolin 1 and 2 are usually both eed and assembled into hetero-oligomers in the endoplasmic reticulum and Golgi apparatus. Caveolin 1 also interacts with lipids and lipid anchors, and may therefore function in both membrane traffic and lipid traffic.
Figure 5 Caveolin-1 inhibits base-line and TGF-1-stimulated phosphorylation of the receptor-linked SMAD (SMAD2). A , NIH-3T3 cells were cotransfected with FLAG-tagged SMAD2 and either Cav-1 or empty vector, incubated in phosphate/serum-free medium supplemented with 32 PO 4 , and selectively treated with TGF-1 (4 ng/ml) for 45 min Caveolin-1 Regulates Transforming Growth Factor (TGF)- Figure 5 Caveolin-1 inhibits base-line and TGF-1-stimulated phosphorylation of the receptor-linked SMAD (SMAD2). A , NIH-3T3 cells were cotransfected with FLAG-tagged SMAD2 and either Cav-1 or empty vector, incubated in phosphate/serum-free medium supplemented with 32 PO 4 , and selectively treated with TGF-1 (4 ng/ml) for 45 min
Caveolin-1 (Cav-1) is the structural protein of plasmalemmal invaginations, termed caveolae, which functions as a tumor suppressor gene. Interestingly, Cav-1 dominant-negative mutations are exclusively found in ER-positive breast cancer samples. In support of these clinical findings, ER eion is increased in Cav-1 (/) null Caveolin-3 homepageCaveolin is a small molecular weight protein shown to be associated with the caveolar plasma membranes. Caveolin-3, or M-caveolin, was identified as a muscle-specific form of the caveolin family (Way, Tang). In skeletal muscle, caveolin-3 is
Caveolae require the caveolin protein for formation. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signalling molecules. Mammals have three caveolin proteins:caveolin-1 (Cav-1, or VIP21), caveolin-2 and caveolin-3 (or M-caveolin). Increased caveolin-1 in intervertebral disc degeneration Caveolin-1 plays a role in preservation of the NC phenotype. Additionally, it may be related to CLC apoptosis, given its increased eion in degenerated IVDs. Nevertheless, CSD enhanced CLC GAG deposition in vitro, and hence the increased caveolin-1 eion during IVD degeneration may also fa
Caveolin-1 could attract proteins to caveolae the same way that clathrin adaptors attract transmembrane receptors to coated pits and/or function as a molecular motor that powers membrane invagination and budding. There is very little evidence, however, that caveolin-1 functions this way. Multiple Functions of Caveolin-1* - Journal of Biological Caveolin-1 could attract proteins to caveolae the same way that clathrin adaptors attract transmembrane receptors to coated pits and/or function as a molecular motor that powers membrane invagination and budding. There is very little evidence, however, that caveolin-1 functions this way.
View protein in InterPro IPR001612, Caveolin IPR031097, Caveolin-1_inver:PANTHER i:PTHR10844, PTHR10844, 1 hit PTHR10844:SF21, PTHR10844:SF21, 1 hit:Pfam i:View protein in Pfam PF01146, Caveolin, 1 hit Sequence (1+) i. Sequence status i:Complete. This entry has 1 described isoform and 1 potential isoform that is Caveolin-1:role in cell signaling - PubMedCaveolins (Cavs) are integrated plasma membrane proteins that are complex signaling regulators with numerous partners and whose activity is highly dependent on cellular context. Cavs are both positive and negative regulators of cell signaling in and/or out of